• 255–St. Louis tornado May 27, 1896
• 116–Joplin tornado May 22, 2011 (figure incomplete as of this writing)
• 114–Hyatt Regency Hotel Skywalks collapse, Kansas City July 17, 1981
• 100-plus–Steamship Saluda explosion, Lexington, Apr. 9, 1852
• 87–Poplar Bluff tornado May 9, 1927
• 72–St. Louis tornado Sept. 29, 1927
• 72–Katie Jane Memorial Home for the Aged
• 65–Marshfield tornado Apr. 18, 1880
• 55–Six County tornado (southeast Missouri) May 30, 1917
• 42–Tipton Ford train collision, (near Neosho) Aug. 5, 1914
• 38–Ozark Airlines FH-227 crash, St. Louis July 23, 1973
• 37–West Plains dance hall explosion April 13, 1928
• 37–Kansas City (Ruskin Heights) tornado May 10, 1957
• 34–Kirksville tornado Apr. 27, 1889
• 31–Gasconade River railroad bridge collapse Nov. 1, 1855
• 28–Kansas City (Lathrop School) May 11, 1886
• 26–Fire at Wayside Inn Nursing Home, Farmington, 1979
• 23–Cape Girardeau tornado May 21, 1949
• 21–St. Louis tornado  Feb. 10, 1959
• 21–Coates House Hotel fire, Kansas City, January 28, 1978

http://missourinet.learfielddemos.com/2011/05/24/disastrous-missouri